Clinical References

Unique Antimicrobial Effects of Platelet-Rich Plasma and Its Efficacy as a Prophylaxis to Prevent Implant-Associated Spinal Infection

Platelet-rich plasma (PRP) has been increasingly used for a variety of clinical applications. However, very little is known about the antimicrobial activities of PRP. This study, published in Advanced Healthcare Materials (2013), examines the antimicrobial properties of PRP both in vitro and in vivo.

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Union Rates Using Autologous Platelet Concentrate Alone and With Bone Graft in High-Risk Foot and Ankle Surgery Patients

Adjuvant use of autologous platelet concentrate (APC) to assist in bone healing in foot and ankle surgery has not been reported. This study, published in the Journal of Surgical Orthopaedic Advances (2005), examines the clinical results and complications after the adjuvant use of APC in high-risk patients undergoing elective foot and ankle surgery.

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Comparison of Methods for Point of Care Preparation of Autologous Platelet Gel

A platelet gel (PG) is produced by adding calcium chloride and thrombin to a platelet concentrate (PC). This study compares the commercial systems available for the preparation of PG.

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Identification of an Optimal Concentration of Platelet Gel for Promoting Angiogenesis in Human Endothelial Cells

Numerous studies have supported the use of topical blood components to improve wound healing and tissue regeneration. This study in Transfusion (2009) sought to define the most effective platelet gel concentration to promote angiogenesis in vitro.

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Mesenchymal Stem Cells Derived from CD133-Positive Cells in Mobilized Peripheral Blood and Cord Blood: Proliferation, Oct4 Expression, and Plasticity

This article from the June 2005 issue of Stem Cells details study findings that proved not only the presence of “circulating” MSCs in mobilized peripheral blood (MPB) and umbilical cord blood (UB) but also the ability to isolate these MSCs with a common reproducible method based on CD133-positive selection. The study demonstrated that these MPB-MSCs and UCB-MSCs have a potential similar to MSCs derived from bone marrow, such as multi-lineage differentiation and proliferative capacity.

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Platelets and Granulocytes, in Particular the Neutrophils, Form Important Compartments for Circulating Vascular Endothelial Growth Factor

Research findings from Kusumanto, et al. point to the significance of using circulating vascular endothelial growth factor (VEGF) levels as a measurement to better assess prognosis. Study data indicate that platelets and neutrophils are the major cell fractions containing circulating VEGF. More importantly, this research is first to show that the majority of circulating VEGF is contained in neutrophils.

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The Efficacy of Autologous Platelet Gel in Pain Control and Blood Loss in Total Knee Arthroplasty: An Analysis of the Haemoglobin, Narcotic Requirement and Range of Motion

This retrospective study reports improved outcomes following total knee arthroplasty (TKA) in which autologous platelet gel (APG) was applied directly to exposed tissues of the surgical site.

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Ongoing Positive Effect of Platelet-Rich Plasma Versus Corticosteroid Injection in Lateral Epicondylitis: A Double-Blind Randomized Controlled Trial With 2-year Follow-Up

Researchers evaluated the outcomes at a two-year follow-up of two treatment types: platelet-rich plasma (PRP) injection and (the gold-standard) corticosteroid injection for patients with chronic lateral epicondylitis (elbow tendinosis).

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Platelet-Rich Plasma Intra-Articular Injection Versus Hyaluronic Acid Viscosupplementation as Treatments for Cartilage Pathology: From Early Degeneration to Osteoarthritis

This publication reports the findings of a comparative analysis evaluating the outcomes of three different treatments for knee degeneration: platelet-rich plasma (PRP) injection, as well as viscosupplementation and both low-weight and high-weight molecular hyaluronic acid (HA) injections.

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